Antioxidant treatment may decrease cardiovascular risk in women with type 1 diabetes Major grant to investigate estrogen, type 1 diabetes and cardiovascular disease link

Antioxidant treatment may decrease cardiovascular risk in women with type 1 diabetes

The high estrogen levels that typically afford younger women protection from cardiovascular disease appear to instead multiply their risk if they have type 1 diabetes, researchers say.

Why does this disparity and risk exist?" says Dr. Levels of Sirt1 naturally increase in the high-estrogen days of the cycle, but the Harris team has preliminary evidence that diabetes decreases that healthy increase. Peak estrogen levels occur during ovulation, which enables an egg to be released and the uterus to prepare for a potential pregnancy. Obesity, a known cardiovascular risk, is a major risk factor as well for type 2 diabetes.

Also related to this story How Does Diabetes Affect The Body? Ryan A. He expects the response of those treated to normalize to that of healthy controls. This occurs during about day 12-14 of the menstrual cycle. Meningitis is a relatively rare disease, with our estimates for the incidence of meningitis in the UK being about 3.2 cases of meningitis per 100,000 adults. This new study, to be conducted by Augusta University and funded by the National Institutes of Health, will investigate the role of estrogen on blood vessels.

Estrogen seems to be key in the early, rapid aging of their cardiovascular system. For this study, the healthy female controls will not be treated but, for comparison sake, men with type 1 diabetes will be studied at two similar points and undergo the same treatment strategies. The first day of bleeding is considered day 1 and estrogen - and progesterone - levels are low. Claire is Evidence & Policy Manager at the UK and international charity Meningitis Research Foundation (MRF).

Major grant to investigate estrogen, type 1 diabetes and cardiovascular disease link

A $3.3 million grant is to be used to investigate why women with type 1 diabetes are up to three times more likely to develop cardiovascular disease (CVD) when compared to men. Researchers think the hormone estrogen could be the reason why women are at greater risk of conditions such as heart attacks or angina.

Your diabetes personal assistant. Rather than giving the women more estrogen, they are using the natural high and low points of the sex hormone over the course of their natural cycle. To look at blood vessel health, they are using flow-mediated dilation, or FMD, of the brachial artery. Sirt1 has been implicated in both type 1 and 2 diabetes, including playing a role in increasing inflammation in type 1.

Some women will be randomised to different antioxidants including vitamin C and resveratrol to assess how this affects the health of blood vessels, while others will receive placebo. Monitor every aspect of your diabetes. In fact, the MCG researchers are the first to study the impact of antioxidants in women with type 1 throughout their menstrual cycle, Harris says. The technique has been shown to accurately predict future cardiovascular disease and events.

When Should You Wet Your Toothbrush? The healthy women will not receive any treatment. Sirt1 lowers the reactive oxygen species produced by the endothelial cells that line blood vessels and increases the availability of nitric oxide, a powerful natural dilator of blood vessels. High glucose levels are believed to increase levels of oxidative stress, which also inactivates nitric oxide, he says. Type 1 diabetes accounts for 5-10 percent of the nearly 30 million Americans with diabetes.